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              <h1>河北工大学计算医学研究所</h1>
              <h2>Institute of Computational Medicine, Hebei University of Technology</h2>
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            <h3>计算分析非编码RNA的功能</h3>
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            本研究所成立于2015年，以我院的河北省大数据计算重点实验室为依托，特聘北京大学医学部崔庆华教授担任名誉所长和学术指导，所有成员均为我院具有丰富智能信息处理经验的中青年教师，并长期从事医学生物信息学领域研究。</p>
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          <p>研究所自成立以来，已与北京大学医学部基础医学院崔庆华教授实验室、周源实验室建立了长期的合作机制</p>
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                <h2>自然科学基金</h2>
                <p> 现本所承担国家自然科学基金1项，河北省自然科学基金3项，完成河北省自然科学基金5项及多个横向联合课题。</p>


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                <h2>主要论文成果</h2>
                <p>发表SCI论文8篇，中文核心期刊论文10篇。</p>
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                  <p>
                    1、 Li Jianwei, Huang Yan, Yang Xiaoyue, Zhou Yiran , Zhou Yuan. RNAm5Cfinder: A Web-server for
                    Predicting RNA 5-methylcytosine (m5C) Sites Based on Random Forest, Scientific Reports,
                    (accepted).</p>
                  <p>2、Li, Jianwie, Xiaofen Han, Yanping Wan, Shan Zhang, Yingshu Zhao, Rui Fan, Qinghua Cui, Yuan Zhou,
                    TAM 2.0: Tool for MicroRNA Set Analysis,Nucleic Acids Res, 2018, 46(W1), W180-W185.
                    doi:10.1093/nar/gky509.</p>
                  <p>3、Huang Z, Shi J, Gao Y, Cui C, Zhang S, Li Jianwei(*), Zhou y(*), Cui Q(*). HMDD v3.0: a database
                    for experimentally supported human microRNA-disease associations. Nucleic Acids Res. 2018,
                    doi:10.1093/nar/gky1010</p>

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                  <p>4、Ma, Wei，Huang, Chuanbo，Zhou, Yuan(*)，Li, Jianwei(*)，Cui, Qinghua(*), MicroPattern: a web-based
                    tool
                    for microbe set enrichment analysis and disease similarity calculation based on a list of microbes,
                    Scientific Reports, 2017.1.10, 7:1~6</p>
                  <p>5、Li, Jianwei, Wei Ma, Pan Zeng, Junyi Wang, Bin Geng, Jichun Yang, Qinghua Cui, LncTar: a tool for
                    predicting the RNA targets of long noncoding RNAs, Briefings in Bioinformatics, 2015,
                    16(5):806-812</p>
                  <p>6、Li, Jianwei, GAO Cheng, WANG YuChen，MA Wei，TU Jian，WANG JunPei，CHEN ZhenZhen，KONG Wei，CUI
                    QingHua，A
                    bioinformatics method for predicting long noncoding RNAs associated with vascular disease, Science
                    China Life Sciences, 2014, 57(8):852-857</p>
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                      <h3>长非编码靶基因预测系统LncTar</h3>
                      <p>LncTar 是一种适用于长非编码RNA（lncRNA）靶基因预测的工具软件，可以快速准确的对lncRNA调控的基因进行预测。
                        LncTar具有以下优点：（1）对RNA长度无限制，可处理目前已知最大长度的RNA分子；（2）运行速度快；（3）提出了判断两个RNA分子能否相互作用的定量标准，实现了自动化预测；（4）预测精度高，在对目前有实验证据支持的长链非编码RNA和mRNA相互作用中，预测准确率达到了80%。
                      </p>
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                        软件访问网址：<a href="http://www.cuilab.cn/lnctar">http://www.cuilab.cn/lnctar</a>
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                      <h3>miRNAs功能解释及功能预测系统TAM 2.0系统</h3>
                      <p>TAM 2.0是miRNA集合富集分析软件TAM的改进升级版，用户通过TAM
                        2.0不仅能够对科研工作中感兴趣的MicroRNA集合进行功能和疾病调控富集分析，还能获取感兴趣的疾病下调MicroRNA集合与其他疾病下调MicroRNA集合之间的关联性，为研究MicroRNA调控功能的科研工作者们提供了强大的科研利器，具有重要的实际应用价值。</p>
                      <p>
                        软件访问网址：<a href="http://www.scse.hebut.edu.cn/tam">http://www.scse.hebut.edu.cn/tam</a>

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